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Opgen Argus DNA Optical mapping system part 2
Opgen Argus DNA Optical mapping system part 2
#Opgen #Argus #DNA #Optical #mapping #system #part
“mikeselectricstuff”
A look at the microscope part of this system
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The crazy complicated driver board might be a case of resume-driven design in an application where costs were irrelevant.
I think the principle of operation of the fiber shaker is just to continuously shuffle the internal incidences of reflection to avoid hot spots. I think it's mostly just a geometry problem rather than relativistic problem.
12:12 Parakeets in UK??!!
8:00 No, there are many conditions that must be followed with medtech equipment and one of them is that if fex a lid is opened so you can access moving parts the moving parts must be stopped immediately, so there is a reason those relays are there.
Just the laser module would pretty much pay for everything.
There is nonzero chance they were using same driver board for linear motors stages as well – there the choice of power opamps and DSP to drive it is totally apropriate.
I might want to buy that x,y,z stuff, if you're parting it out. The dampeners look ideal for what I have in mind, and as you said IKO is always top notch.
That Lunixx root password can be reset by booting into what's called "single-user mode", followed by a simple 'passwd root' and you're good to go.
I'd like to mention this optical fiber shaker at 4:10 to @HuygensOptics (not sure if this works on youtube and if Jeroen from @HuygensOptics is pinged now)
That's some nice piece of engineering and since it runs on Linux, I could probably hack my way in if I laid my hands on this thing. A nice workstation grade MB there, and he connectors on the brackets at 6:32 are just standard ATX 20+4 and 2×4 power supply connectors for the board, so you can easily disconnect the supply to pull out the platform or test i out of the device. HDDs on the bottom side of the chassis are a nice touch. I'm wondering about the system specs, especially the CPU type.
That's definitely a nice laser! That goes on a shark's head.
Lovely CCD assembly too.
The images at the end remind me more of astronomy or particle physics than biology, but then I'm a chemist and an electronics engineer, not a biologist π
fascinating the way the speckle is reduced with vibration. I like the XY table mechanics but its probably not as usable as one might hope. Great video, very neat stuff
That is a mode scrambler. Used for making it a pure color of light like a very bright led. These units generally have a 488nm and 635nm laser as well as the 532nm laser. If this one only had a 532nm in it, it was uses for an extremely specific kind of test. That photometrics camera is what was inside a Coherent laser beam mode analyzer with a heavy duty attenuator, they cost a fortune back then. 562nm is the emission peak of florescent green πͺΌ protein. π
The analog stepper drivers could be for emi reduction
The shaker on the optical cable operates in much the same way as a galvanometer in that it changes the angle of reflection in the optical cable thereby effectively blurring the speckle effect.
I do not have any personal knowledge of optical mapping methods but the Wikipedia article seems to explain the workflow well enough: https://en.m.wikipedia.org/wiki/Optical_mapping
thanks!!
Awesome bit of kit !….cheers.
Maybe the motors aren't steppers, but DC servo motors with ultra precise feedback control?
I recently had a chance to pull apart a $0.5 M AUD genetics instrument in a 2 cubic meter size enclosure. Aside from the incredible build quality and over-engineering, the most incredible thing is how quickly these kind of equipment go out of relevance. The unit was only 5 years old an no longer supported (critical consumables no longer manufactured) and practically obsolete in terms of performance.
That unbalanced motor fiber jiggler thing just blew my mind. I've never seen that implementation for despeckling done before! It's such an elegant and parsimonious solution! The lengths we have to go to in order to suppress speckle on inertial confinement fusion targets is insane: distributed phase plates, smoothing by spectral dispersion, distributed polarization rotators… all to the tune of many tens of millions of dollars. Of course, we also have to do it on picosecond timescales, so there's that little caveat too.
If you can get the hard disks to me I will try to do some forensic digging on there to see if there is anything interesting.